.  . 66
. . 


        ,           20182019 .   ,     .







 . 66



 . . 



ISBN978-5-0050-4330-6 (. 66)

ISBN978-5-0050-4331-3

     Ridero


		 .  66.  .

 . .:  Ridero, 2019. 144.

  .

 ,  .

 613.98; 612.67/.68

 28.07153.4

      

,    

    20182019.

  ,    .

		 :

..,  ,  ;

.., ...,  ;

.., ..., ..., , ;

    :

   ;

.   

.             (  ).

  :

novoselovvm@mail.ru (mailto:novoselovvm@mail.ru)




 





          Ƞ     

.., ..


         .        .           .       .    ,        .     ,      .           .         .

		

     ,     (Blumenthal, 2006; Donmez and Guarente, 2010; Marengoni et al., 2011; Bulterijs, 2012; Gems, 2014; Rattan, 2014; Zhavoronkov and Bhullar, 2015; Bulterijs et al., 2016; Lustgarten, 2016; Zhavoronkov and Moskalev, 2016; Moskalev et al, 2017).          ,    ,    ,  ,    .  ,            (Spindler, 2012; Rattan, 2014; Krutko at al., 2016; Moskalev at al, 2016, 2017).       anti-aging medicine.

               ,         .

		   

     ,      .

,        ,        ,    . ʠ,       : ,     (,  .).

    ( )  ()  ,      

        ,     ࠖ      .

      ,      ,          :      -  , -,    ,   .   ,  ,        .

  ,      ,      ,         ,          ,  -  ,       黠            .

    ,             .

  ,   ,     ,        ,  ,        .

             ,                (Hayflick, 2007; Kirkwood andMelov, 2011; Walker, 2011; Rando and Chang, 2012; Khokhlov, 2013; Dontsov and Krut`ko, 2015; Jones, 2015; Khalyavkin andKrutko, 2015; Liochev, 2015; Pinto and Moraes, 2015).

,  ,   ,      .

      (Dontsov, 1998; Krutko at al, 2009)        ,                .

  ,           ,         .

         : ,   , ,  .

 ,           : , , ,  ,  .,     .

      ,         ,              ,    .

         .. ⠖      ,       -  (Spindler, 2012; Rattan, 2014; Krutko at al., 2016; Moskalev at al, 2016, 2017).

  ,      ,   ,     .

		      

    .

              ( ).

     .          .      :      , ,          .          .

       ,     .          ,     .

     ,      ,   ,      頖 .

    ,     .             .   .            .       , ,  ,  ,        .

, ,           ,    ,    ..

 ,          堖  ,             .

		,    

       ,      ,    : , , ,  . , ,     ,        .            .

 ,              (), ..       (Spindler, 2012; Gems, 2014; Krutko et al, 2016; Moskalev et al, 2016, 2017)..   , ,   (Strong et al. 2008; Flurkey et al., 2010),  (Barzilai, 2016),  (Harrison et al. 2009)    (Spindler, 2012; Moskalev, 2015, 2016).

               (500/).

  ,          ,  .    Balb/c   (30/ 2 ), 17-   13          67%  7%   (Khansari and Gustad, 1991).

  젖      ,  - ,         (Nikolai et al, 2015; Kalra et al, 2016; Roth and Ingram, 2016).

        - (Krutko at el., 2016).

		

        4 /    :

1)      젖      ;

2)     (    ,     ,        );

3)   ;

4)      .    ,      .

     , ..      ,        .       .

ʠ       ,          ,   .

                  .

		

BabaevaA.G.Reparative processes and immunity. Izv Akad Nauk Ser Biol. 1999. 3: 261269. Review. Russian.

BabaevaA.G., ZuevV.A.Transfer ofsigns ofaging toyoung mice bysplenic lymphoid cells from old syngeneic donors..Bull. exp. biol. med. 2007. 1441: 8990.

Barzilai N., CrandallJ.P., KritchevskyS.B. and Espeland, M.A.Metformin as aTool toTarget Aging. Cell Metab. 2016. 236: 10601065.

BlumenthalH.T.The aging-dise as e dichotomy: true or false J. Gerontol. Med. Sci. 2006. 58A: 138145.

Bulterijs S. The future oflongevity. Pan Eur. Netw. 2012. 5: 116117.

Bulterijs S., HullR.S., BjorkV.C. et al. It is time toclassify biological aging as adisease. Front. Genet. 2016. 6:205.

Donmez G., Guarente L. Aging and disease: connections tosirtuins. Aging Cell. 2010. 9, 285290.

DontsovV.I.Lymphocyte regulation ofcellular growth insomatic tissues and anew immune theory ofaging. Fiziol Cheloveka. 1998. 241: 8287. Russian.

DontsovV.I., Krut`ko V.N.Biological age as amethod for systematic assessment ofontogenetic changes inthe state ofan organism. Russian journal ofdevelopmental biology. 2015. 465: 246253.

Flurkey K., AstleC.M., HarrisonD.E.Life Extension byDiet Restriction and N-Acetyl-L-Cysteine inGenetically Heterogeneous Mice. J Gerontol ABiol Sci Med Sci 2010. 65A: 12751284

Gems D. What is an anti-aging treatment? Exp. Gerontol. 2014. 58: 1418.

HarrisonD.E., Strong R., SharpZ.D. et al. Rapamycin fed late inlife extends lifespan ingenetically heterogeneous mice. Nature. 2009. 460, 392395.

Hayflick L. Entropy explains aging, genetic determinism explains longevity, and undefined terminology explains misunderstanding both. PloS. Genet. 2007. 3: 220224.

Jones, D. P.Redoxtheoryofaging. Redox Biol. 2015. 5: 7179.

Kalra S., JacobJ.J., Gupta Y. Newer antidiabetic drugs and calorie restriction mimicry. Indian J Endocrinol Metab.2016. 201: 142146.

KhansariD.H., Gustad T. Effect oflong-term, low-dose growth hormone therapy on immune function and life expectancy ofmice. Mech. Ageing Dev. 1991. 57: 87100.

KhalyavkinA.V., Krutko V.N.Early Thymus Involution-Manifestation ofan Aging Program or aProgram ofDevelopment? Biochemistry Moscow. 2015. 8012: 16221625.

KhokhlovA.N.Impairment ofregeneration inaging: appropriateness or stochastics?// Biogerontology. 2013. 146: 703708.

KirkwoodT.B., Melov S. On the programmed/non-programmed nature ofageing within the life history. 2011. Curr. biol. 2118: 701707.

Krutko V.N, DontsovV.I., Zakhariashcheva O.V.The system theory ofaging: methodological principles, basic tenets and applications. Aviakosm Ekolog Med. 2009. 431: 1219. Review. Russian.

Krutko V.N., DontsovV.I., KhalyavkinA.V.Effect ofalphafetoprotein on lifespan ofold mice. Biochemistry Moscow. 2016. 8112: 14771479.

LiochevS.I.Which is the most significant cause ofaging? Antioxidants Basel.2015. 174: 793810.

LustgartenM.S.ClassifyingAgingAs aDisease: The Role ofMicrobes. Front Genet. 2016. 1, 7: 212; eCollection 2016.

Marengoni A., Angleman S., Melis R. et al. Aging with multimorbidity: asystematic review ofthe literature. Ageing Res. Rev. 2011. 1(10): 430439.

Moskalev A., Chernyagina E., Tsvetkov V. et al. Developing criteria for evaluation ofgeroprotectors as akey stage toward translation tothe clinic. Aging Cell. 2016. 15: 407415.

Moskalev A., Chernyagina E., Kudryavtseva1 A. et al. Geroprotectors: AUnified Concept and Screening Approaches. Aging and Disease.2017. 834: 110.

Nikolai S., Pallauf K., Huebbe P. et al. Energy restriction and potential energy restriction mimetics. Nutr Res Rev. 2015. 282: 100120.

RattanS.I.S.Aging is not adisease: implications for intervention. Aging Dis. 2014. 5: 196202.

Pinto M., MoraesC.T.Mechanisms linking mtDNA damage and aging.Free Radic Biol Med. 2015. 85: 250258.

RandoT.A., ChangH.Y.Aging, rejuvenation, and epigenetic reprogramming: resetting theagingclock. Cell. 2012. 14812: 4657.

RothG.S., IngramD.K.Manipulation ofhealth span and function bydietary caloric restriction mimetics. Ann N Y Acad Sci. 2016. 3631: 510.

SpindlerS.R.Review ofthe literature and suggestions for the design ofrodent survival studies for the identification ofcompounds that increase health and life span. Age. 2012. 341: 111120.

Strong R., MillerR.A., AstleC.M. et al. Nordihydroguaiaretic acid and aspirin increase lifespan ofgenetically heterogeneous male mice. Aging Cell. 2008. 7: 641650

Zhavoronkov A., Bhullar B. Classifying aging as adisease inthe context ofICD-11. Front Genet. 2015. 4, 6:326.

Zhavoronkov A., Moskalev A. Editorial: Should We Treat Aging as aDisease? Academic, Pharmaceutical, Healthcare Policy, and Pension Fund Perspectives. Front Genet. 2016. 16, 7:17.

WalkerR.F.Developmental theory ofaging revisited: focus on causal and mechanistic links between development and senescence. Rejuvenation res. 2011. 144: 429436.

		 ADEVELOPMENT THE TYPICAL FOR COMMON DISEASE SYNDROMES INTHE COURSE OFNATURAL AGING AND THE VALIDITY OFTHEIR CORRECTION USUAL MEDICAL MEANS
		V. N.Krutko, V. I.Dontsov

AGeneral approach toaging is possible only on the basis ofthe General System theory ofaging. The system theory ofaging is based on the General Model ofaging ofBiosystems. This model includes aging Syndromes as the most important level ofaging development and is the same as the typical syndromes for any disease. This allows us todiagnose, treat and prevent aging syndomes as syndromes ofany disease. Additional is the development ofAge-related diseases, which also requires diagnosis and prevention also during aging. All this allows an ordinary doctor totreat the manifestations ofaging as manifestations ofdiseases. This makes the effects on aging accessible and understandable tothe Clinician.




  -   ,      

..


       蠫.        ,     . ,        - ,       ,      .      -  .




  .


   .

   ,     (https://www.litres.ru/v-doncov-19615973/doklady-moip-seriya-gerontologiya-tom-66/)  .

      Visa, MasterCard, Maestro,    ,   ,     ,  PayPal, WebMoney, ., QIWI ,       .


