-       
  


          .            .                ,  ,    .  -         .    -        .         .    ,   .





 

-       










   (Restless leg syndrome)   -  ,    ,  , , ,      ,       .             .      ,   ,   .         ,   ,   ,     -     .

     ,       ,     .    ,   ,  ,      .

     ,    ,   . . ,        , .        .   (  ), - .














  




  

        ,      . ,  (Vishal, Snehal, 2017).

       (International Restless Legs Syndrome Study Group, IRLSSG)   ,         U.R.G.E        ,       ;

  ,          ;

  ,        / ;

                    .






   


 ()  ;

 ()  ;

     ;

     (  ).




   




 () :        2       .

 :         2   ,    5    .

 .          .

  ,          5  15%  ,     . 38% c       20   10%  10  (Winkelmann et al.,2018).    .   ?     (pregnancy-related RLS),   3-          (Panvatvanich, 2019).  2-4%         ()       , ?2?-    (Zucconi, 2018).           ,      ,     (,2016; , 2018; Winkelmann et al.,2018). -              (Cho, Kim, 2017; Yilmaz, ?2018).     ,              ( ,  ,  ,   ),   ;       , ,  ,        (Zhuang, 2019; Kallweit, 2016; Winkelmann, 2005; Kim, 2013).   ,      ,     - .   ,       (Innes, 2012; Li, Winkelman, 2018).

         30  90%, ,     , ,    (Harrison,2019). ,   ,   ,   D       .      rotigotine     (Vishal,Snehal, 2017).

   ,  -   (, , 2011; , 2016; , 2016).      80%    ,       (, , 2011).          ,     .    ,          ,   . ,  ,  . ..          (, 2016; Kwatra, Khan, 2018).            ,          .

   ,  -  .      80%    ,       ,       .             .    ,          ,   .   1945  K.  ,        ,      .

                           .




     




        ,         .     45   ,    ,  45   .      , ,         .    ,    ,   ,      (, 2016; Hugh Selsick,2018; Hrayr P.Attarian, 2017; Vishal, Snehal, 2017).

    . ,             .     ,     .             ( , -     ).    -   ,   D2    ,    3-O-methyldopa   .   ,          .           (SF)   . ,   D2-         (Gonzalez-Latapi, ?2019)

     .      , ..    -   .             H-.         .               (Vishal, Snehal, 2017)

    . ,         .           11C-diprenorphine   ,   ,   .       (Gonzalez-Latapi, ?2019).

     ,             (Hugh Selsick,2018).

   ,    .     ,       54-83%.         MEIS1, BTBD9, MAP2K5/SKOR1, PTPRD  TOX3,  -     (Hrayr P.Attarian, 2017).

,           (RLS-like symptoms).  ,     (imipramine)   (citalopram, escitalopram, fluoxetine, sertraline, paroxetine, trazodone, venlafaxine, dutoxetine, mirtazapine).                . ,      (olanzapine, risperidone, quetiapine).  ,   H1 ,       (metoclopramide, prochlorperazine, Kwatra, Khan,2018).



      . ,  , ,   ,  (  ,     ), ,      .   ,    ,      (URGE),           .       (URGE)     85%  (, 2016; Kwatra, Khan,2018).






-  


    ,  ,              .

.     (Chavda Vishal, 2017)  -    .

              (URGE).   ,       .           (   ).          ( ,    ).          (, , )  ,      .   ,      (, 2016; , 2016; Kwatra, 2018; Hugh Selsick,2018; Hrayr P.Attarian, 2017).

 : 1)   ,      ; 2)     ; 3)      ; 4)        (        (, 2016).

                      (International Restless Legs Scale Rating Scale, IRLS-RS);      (Johns Hopkins Restless Legs Severity Scale, JHRLSS)      (Restless Legs Syndrome-6 Scales, RLS- 6) (, 2016; Hugh Selsick,2018; Hrayr P.Attarian, 2017).

                 (RLS quality of life questionnaire, RLSQOL).          ,   ,    .           (Abetz, 2005).

       (Restless Legs Syndrome Foundation; International Restless Legs Syndrome Study Group)         (mood disturbance)          (Becker, ?2014). ,       (The hospital Anxiety and Depression Scale, HADS, A.S. Zigmond, R.P. Snaith);     (Hamilton Depression Rating Scale, HAM-D, HDRS).

            :       (HADS);     (Hamilton Anxiety Rating Scale, HAM-A)        (Generalized Anxiety Disorder 7-item scale, GAD-7)

           :      (Pittsburgh Sleep Quality Index, PSQI, D.J, Buysse);    (Insomnia Severity Index, ISI, . Morin)     (Athens Insomnia Scale, AIS).

           (Epworth sleepiness scale, ESS)

                 ,      .    5            

  ,  (, , , ,   .)        SCL-90-R (Simptom Check List-90-Revised)

       - 20  (20-item Toronto Alexithymia Scale, TAS-20)

       (, , )       .  (Scale for Suicide Ideations, SSI).

  ,               .  (Eysenck's Personality Inventory, EPI)

    -           (Maudsley Obsessive-Compulsive Inventory, MOCI)






     .   .




,               -  (Kallweit, 2016).    ,  ,      ,             (Lee, 2014).

                  (anxietas tibiarum, J. Winkelmann, 2005)

      ,      .     .  ,   ,       ,     . , ,   , , , , ,        .

  ,                    ,       .     .    ,       ,    (Koo, ?2016).    -  ,          (Para, 2018).

,           ( 3  )   ,   .     , ,  ,   ,  .  ,           (Para, 2018; Zhuang, 2019),

     5 ,     PubMed, Science Direct, SpringerLink  Springer     -,                  ,        30-40   ,       .

  Ellen Trautmann  . (2015[1 - Trautmann E., Barke A., Frisch J.U. Restless Legs Syndrome: Psychiatric Comorbidities Are More Important Than Neuroticism. // Behav Sleep Med. 2015;13(5):375-86.]) ,             ( , ),        



       (.3)   ,    -   .      ,       .         .  . ,        , ,          () .     .     .     . ,     ( SCL-90-R),   ,    (Jung Bin Kim, t al, 2013).  ,            .    ,         . ,         ( SCL-90-R)             (Jung Bin Kim, t al, 2013). ,              (Scholz et al. 2011     ,             ( , )   . ,        ,         .         ,     (Scholz et al. 2011).     ( ,   )            (Para, 2018).           (Lin, 2018).      32-58%   ,         (Bishop, 2018).  S. Zhuang  . (2019) ,                 , , ,  .             .      .         - ,        (Zhuang, 2019).

             . ,       (Kolla, ?2018). ,      ,           .  ,           .  ,        .  ,          . , -                    (Zhuang, 2019).

           ,    .    ,        ,   .    ,             (Hugh Selsick,2018; Hrayr P.Attarian, 2017).

             (SCL-90-R).         (Jung Bin Kim t al, 2013)




  .


   .

   ,     (https://www.litres.ru/aleksey-igorevich-me/kognitivno-povedencheskie-rekomendacii-po-snizheniu-d/)  .

      Visa, MasterCard, Maestro,    ,   ,     ,  PayPal, WebMoney, ., QIWI ,       .



notes








1


Trautmann E., Barke A., Frisch J.U. Restless Legs Syndrome: Psychiatric Comorbidities Are More Important Than Neuroticism. // Behav Sleep Med. 2015;13(5):375-86.


