   COVID-19
  


        ,        COVID-19,    ,       .





   COVID-19



  



  ,2020



ISBN978-5-0053-0202-1

     Ridero


  Π COVID-19 







 ................................................................3

.4

充..4

    ,   COVID 19...6

  COVID 19..15

     ԅ..19

    ԅ..20

 COVID-19 腅...29

    腅.33

  COVID 19 腅.

 COVID 19.39

 ,   酅.57

    ԅ .60

    COVID-19..61

   򅅅..62

    COVID-19..65

 COVID 19.66

   COVID 19....67

 񅅅.70

    COVID-19............ 71

  COVID-19...72

   充...74

   .. .78

     COVID-19. .80

....89

. 91







        COVID-19        .   COVID-19     ,      ,    ,              , ,   .

      COVID-19  ,          .     , ,     -  .







     (https://ru.wikipedia.org/wiki/%D0%A3%D1%85%D0%B0%D0%BD%D1%8C),  (https://ru.wikipedia.org/wiki/%D0%9A%D0%B8%D1%82%D0%B0%D0%B9),  2019[4] (https://ru.wikipedia.org/wiki/%D0%9F%D0%B0%D0%BD%D0%B4%D0%B5%D0%BC%D0%B8%D1%8F_COVID-19#cite_note-4)[5] (https://ru.wikipedia.org/wiki/%D0%9F%D0%B0%D0%BD%D0%B4%D0%B5%D0%BC%D0%B8%D1%8F_COVID-19#cite_note-5). 30 2020   (https://ru.wikipedia.org/wiki/%D0%92%D1%81%D0%B5%D0%BC%D0%B8%D1%80%D0%BD%D0%B0%D1%8F_%D0%BE%D1%80%D0%B3%D0%B0%D0%BD%D0%B8%D0%B7%D0%B0%D1%86%D0%B8%D1%8F_%D0%B7%D0%B4%D1%80%D0%B0%D0%B2%D0%BE%D0%BE%D1%85%D1%80%D0%B0%D0%BD%D0%B5%D0%BD%D0%B8%D1%8F)      ,    (https://ru.wikipedia.org/wiki/%D0%A7%D1%80%D0%B5%D0%B7%D0%B2%D1%8B%D1%87%D0%B0%D0%B9%D0%BD%D0%B0%D1%8F_%D1%81%D0%B8%D1%82%D1%83%D0%B0%D1%86%D0%B8%D1%8F_%D0%B2_%D0%BE%D0%B1%D0%BB%D0%B0%D1%81%D1%82%D0%B8_%D0%BE%D0%B1%D1%89%D0%B5%D1%81%D1%82%D0%B2%D0%B5%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B4%D1%80%D0%B0%D0%B2%D0%BE%D0%BE%D1%85%D1%80%D0%B0%D0%BD%D0%B5%D0%BD%D0%B8%D1%8F,_%D0%B8%D0%BC%D0%B5%D1%8E%D1%89%D0%B0%D1%8F_%D0%BC%D0%B5%D0%B6%D0%B4%D1%83%D0%BD%D0%B0%D1%80%D0%BE%D0%B4%D0%BD%D0%BE%D0%B5_%D0%B7%D0%BD%D0%B0%D1%87%D0%B5%D0%BD%D0%B8%D0%B5), 11ࠖ [6] (https://ru.wikipedia.org/wiki/%D0%9F%D0%B0%D0%BD%D0%B4%D0%B5%D0%BC%D0%B8%D1%8F_COVID-19#cite_note-6)[7] (https://ru.wikipedia.org/wiki/%D0%9F%D0%B0%D0%BD%D0%B4%D0%B5%D0%BC%D0%B8%D1%8F_COVID-19#cite_note-7).  30 2020,      63,4    ;  1,471    43,8 [8] (https://ru.wikipedia.org/wiki/%D0%9F%D0%B0%D0%BD%D0%B4%D0%B5%D0%BC%D0%B8%D1%8F_COVID-19#cite_note-8).[1.]

      ,        ,    ,         COVID19.



    



  (ACE).   Alu Ins/Del (  )

 ࠖACE

OMIM (https://helix.ru/kb/dict/OMIM)+106180 (http://www.omim.org/entry/106180)

  堖 17q23.3



 (https://helix.ru/kb/dict/%D0%93%D0%B5%D0%BD)Š -  ()    (),         (http://helix.ru/kb/item/06-019),   I II.

 Alu Ins /Del

 16-  Š - (I/D) (https://helix.ru/kb/dict/%D0%9F%D0%BE%D0%BB%D0%B8%D0%BC%D0%BE%D1%80%D1%84%D0%B8%D0%B7%D0%BC%20%20%D0%B3%D0%B5%D0%BD%D0%B0),   (, I)   (, D) Alu-,  289 (https://helix.ru/kb/dict/%D0%9D%D1%83%D0%BA%D0%BB%D0%B5%D0%BE%D1%82%D0%B8%D0%B4).  Alu-   (https://helix.ru/kb/dict/%D0%AD%D0%BA%D1%81%D0%BF%D1%80%D0%B5%D1%81%D1%81%D0%B8%D1%8F%20%20%D0%B3%D0%B5%D0%BD%D0%B0)ACE.

 (https://helix.ru/kb/dict/%D0%93%D0%B5%D0%BD%D0%BE%D1%82%D0%B8%D0%BF)

I/I

I/D

D/D

  

 ,

  ,

 ,

 ,

  ,

 (http://helix.ru/kb/item/734),

  ,

.

  

      -  ().

    ,   ,      ,     .   -   II,    ,        (http://helix.ru/kb/item/08-013),     ,     .             .

   I(  䠖  10 Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu)    II (  2-His-Leu)  -  ()     ().    Ԡ .

   ,    ,  .     ,     ,   ,    ..

          5. Ӡ     .        (https://helix.ru/kb/dict/%D0%9F%D0%BE%D0%BB%D0%B8%D0%BC%D0%BE%D1%80%D1%84%D0%B8%D0%B7%D0%BC%20%20%D0%B3%D0%B5%D0%BD%D0%B0).  16- (https://helix.ru/kb/dict/%D0%98%D0%BD%D1%82%D1%80%D0%BE%D0%BD)  - (I/D) ,   (, I)   (, D) Alu-,  289 (https://helix.ru/kb/dict/%D0%9D%D1%83%D0%BA%D0%BB%D0%B5%D0%BE%D1%82%D0%B8%D0%B4). (https://helix.ru/kb/dict/%D0%94%D0%B5%D0%BB%D0%B5%D1%86%D0%B8%D1%8F)Alu-   (https://helix.ru/kb/dict/%D0%AD%D0%BA%D1%81%D0%BF%D1%80%D0%B5%D1%81%D1%81%D0%B8%D1%8F%20%20%D0%B3%D0%B5%D0%BD%D0%B0)ACE   ,  ,   ,    -  ( ,   ,   ),  , ,  .

Ӡ,  (https://helix.ru/kb/dict/%D0%93%D0%BE%D0%BC%D0%BE%D0%B7%D0%B8%D0%B3%D0%BE%D1%82%D0%B0) (https://helix.ru/kb/dict/%D0%90%D0%BB%D0%BB%D0%B5%D0%BB%D0%B8)D ( (https://helix.ru/kb/dict/%D0%93%D0%B5%D0%BD%D0%BE%D1%82%D0%B8%D0%BF)D/D),    2  I/I.  D/D-     ,  ,  , -             .

      ()      .  (https://helix.ru/kb/dict/%D0%93%D0%B5%D0%BD%D0%BE%D1%82%D0%B8%D0%BF)I/I 4,5   ,  ,  , , -,  .

 Š     ,       (   ,     ),    D/D  .

 D-       .

 I     .                 . ,      I     (  I/I  2 ,    D/D)   ,   .[2.]

 ,   -    I,  .

      ,   /.       .     12  9,437/.  1316       .    9,033,4/.        6,126,6/.[3.]

   :     :  6 1890U/I714 25121U/I1518 18101U/I 18   ,   967U/I.[4.]

 2    :



    ,   .     -.

 (,    ,   .

  ,    .     , , .

     .    ,  .       -    (,  ).

          (, , , ).        (, , ).

     ,     .[4.]



    ?        .  2      ,    . 2     ,   - . ?         ,   , -  -       ,    .       COVID-19.

      2  .   ,      7  ,   ,      ,   .        2   COVID-19.

 1990.     ,   (I)   (D) 16-  287  [37].        ,       D. ,  [38] 80  ,       II, ID DD     299, 393494/.     [2]:    DD    2 ,   

II/ID.[5.]

    17q23.           (/; D/I) 287bp  16 .    ,      .       ,    DD      ,  II      ,      (Rigat B.1990).[6.]

  ELSA   320    DD              ,  ,  II ID .    Amant .,       146   .     DD           .[6]

 -  ,     D .  ACE   ,  D ,    ,   I     ID .  ACE      ,   ,   ,     ,     .[7.]

 ,  D  ACE          , ,   . Ӡ   .    ACE    (. 2)  ?2  (p = 0,030),   (p = 0,024).    (p = 0,010), ,   (? = 0,53; p = 0,004). ,    ,       I  D     ()[7.]

.     :     ,         , ,  ,         . ,  [1] ,   DD       .        (1- 35, 2- 3548 3-  48)     DD:  33,9; 44,419,1%.     DD 2-      .    ,   DD  36,5% ,      35, 21,6% ,      3548.     3-          ,      ,         .[5.]

 ,   ,         COVID 19,   , ,          .  ,  , ,     DD   .

           .   ,       ,   I/D D/D,    ,        ,     I/I.     ,    I/I ,       ,      D/D       .  ,        I/I, -,   ,       .[8.]

         DD . (,   COVID 19      .)    ,     -   .     ,           ,      .       II,          ,      ,    ,     ,       .[7.]

,        ,      -  .

       . ,        2,              .



  COVID19



       2. Ӡ,      2,    ,  ,      . ,   .        2.     ,      II  ID 2.[5.]

         I/D    [43].   20   II DD (10  ),       4.       .       ,    II      ,   DD  .  ,   II        ,      .[5.]

 ,    ,   ,   I/D       ,   D   .      I,  ,              I/D    . -,       ,        .    D       ,  ,  ,  ,  I    );      I/D    ,        DD  à[5].

           ,    ALLHAT      , ,      .    815255(0,1%), 39048(<0.1%) 389054(0,4%)   ,    /39/.        :   (25369[<0,1%]  , 233210[0,7%]  ;  <0,001)   (69886[0,1%]   155844  [0,3%];  0,002). '       .        ,           .             .      ,          .    .[9.]



,                  .    ( )        . (           COVID 19.) , ,      , ,     44%   (46% ,  , 41,8% ,  ).         .

          .      ,    .      ,       ,    , 26% 15% , . ,  ,     ,   . ,                 . ( ,       2.)          .          ,   .      Ѡ    J ,   . [10.]

(    ,         .)

  P     ,  Ѡ    .         .   ,    ,   - .         .     ,   16%       .       ,  ,         / [10.]



(,    ,     .         ,   ,     COVID-19   2. ,  ,       .         .   ,       2,   ,     2   ,    .)

  , ,  .        ,   ,     .      ,     .  , ,   ,      .  ,    ,        .    ,       . [10.]

,   ,     ,   ,     ,   .

(         .)

       .    ,     ,         (, ,  , , ).      ,        ( ,  , ).  ,        (, ). [10.]



    



 ,    II ,     .       .   ,  ,   ,    .

            ,           ,   . Ƞ-,      ,   ,      .

   (      0,5/)  16%    12%   ,  , ,  ,  4%      .      ,      ,       ,     ?-        . [10.]



   



      .

    )      .       (Ig) (  I),   (, 5),  ,    .          ().      , PGE2    2-.    NO ,   2-         2+.  2-     ,     NO.       ,  -    (2-),  (2-),   (1-)    (1-).      .       ,        ,  .     .           . ,  ,     ,  ,      ()   .        .  2-    HCl .       2-.   I ( ,  /,  )   .) .     .     , ,   (  ),    ( II),      .         XII.       (  1)   . )     :   ,   ,  , ,     ,      ,  .         .      ,   .     (  ),   (   ),   . [30.]



        COVID-19.

         0,10,3%      .

      , ,   , ,    .

            .       ,    .

 ,        , , ,      .

     .      ,     .   163       21%     24.  , 20%  6. .  ,      3.  .

          젖 .          ,   ,     0,006%,   320    0,3%.          ,             [36]. (Ƞ        COVID 19  .)

     ,         .

         ,    ,  ,        . ,      ,   ,      ,       , ,         .    ,     ,   , ,    . ,   4970       122 10     ,  , 8,2%        .

ʠ      .           ,      .

ChaseM.P. et al.      72- ,     ,  .

         .    ,  1.      ,    24.    .         1 .

,           (  ),     .

               . [10.]

         4,5 ,  .        ,     (        )  .

        .      ,      ,    COVID 19.   ?

1)       .     (44-46%)     ,      .

2)    , ,    .          .   ,         .  ,       ,  ,     (6001200/).  ,     (<150/),    . (           2  COVID19.)

  15% ,     .  ,   ,       ,     .      4- .   (     ).    ,      ,       .

3)        ,    .           젖 .        47351  ,   ,     0,006%,   320    0,3%.          ,             [36]. (            COVID19.)

     ,         ,      .

4)  ,       . ʠ      .           ,      .

ChaseM.P. et al. [38]      72- ,     ,  .

         .    ,  1.      ,    24.    .         1 .




  .


   .

   ,     (https://www.litres.ru/pages/biblio_book/?art=63619521)  .

      Visa, MasterCard, Maestro,    ,   ,     ,  PayPal, WebMoney, ., QIWI ,       .


