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 Jennifer A. Daudna, Samuel H. Sternberg, 2016

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 . ,  , , 2019

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   ,     ,    ,    ࠖ [11 - B.R.Davis and F.Candotti, Revertant Somatic Mosaicism in the Wiskott-Aldrich Syndrome, Immunologic Research44 (2009): 127131.](   1020%       )      [12 - E.A.Kvittingen et al., Self-Induced Correction of the Genetic Defect in Tyrosinemia Type I, Journal of Clinical Investigation 94(1994): 16571661.].             :    ,     [13 - K.A.Choate et al., Mitotic Recombination in Patients with Ichthyosis Causes Reversion of Dominant Mutations inKRT10, Science 330(2010): 9497.],     ,  .      ,   ,      .

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   ,     (https://www.litres.ru/dzhennifer-daudna/treschina-v-mirozdanii/)  .

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notes








1


  蠖   .      ,        (. . .).




2


 ,    .   ,        , ,        .     ,  ,      . . Eleftheria Palkopoulou et al. Genomic history of extinct and living elephantids, Proceedings of the National Academy of Sciences, Mar 2018, 115(11), E2566 E2574; DOI:10.1073/pnas.1720554115.    ,   (*),   ,  . ,  ,     .




3


    ,       .  2017,     Homo sapiens   -, ,      200 . . Jean-Jacques Hublin et al. New fossils from Jebel Irhoud, Morocco and the pan-African origin of Homo sapiens, Nature, volume 546, pages 289292(08June 2017), DOI: 10.1038/nature22336.




4


 堖  ,       ;                 .




5


    .   ,      HTT,   ࠖ    .




6


D.H.McDermott et al., Chromothriptic Cure of WHIM Syndrome, Cell 160(2015): 686699.




7


WHIM     : warts (), hypogammaglobulinemia (,    ), infections () myelokathexis (,      ).




8


P.J.Stephens et al., Massive Genomic Rearrangement Acquired in a Single Catastrophic Event During Cancer Development, Cell 144(2011): 2740.




9


R.Hirschhorn, In Vivo Reversion to Normal of Inherited Mutations in Humans, Journal of Medical Genetics 40(2003): 721728.




10


R.Hirschhorn et al., Somatic Mosaicism for a Newly Identified Splice-Site Mutation in a Patient with Adenosine Deaminase-Deficient Immunodeficiency and Spontaneous Clinical Recovery, American Journal of Human Genetics 55(1994): 5968.




11


B.R.Davis and F.Candotti, Revertant Somatic Mosaicism in the Wiskott-Aldrich Syndrome, Immunologic Research44 (2009): 127131.




12


E.A.Kvittingen et al., Self-Induced Correction of the Genetic Defect in Tyrosinemia Type I, Journal of Clinical Investigation 94(1994): 16571661.




13


K.A.Choate et al., Mitotic Recombination in Patients with Ichthyosis Causes Reversion of Dominant Mutations inKRT10, Science 330(2010): 9497.




14


J.Lederberg, Ome Sweet Omics A Genealogical Treasury of Words, Scientist, April 2, 2001.




15


   , ,       ,   ( ) .




16


      .            ()   .   ,   ,   .      .     ,  .     ,     -.




17


  ;    ,  .




18


 2018   : Shiyu Luo et al. Biparental Inheritance of Mitochondrial DNA in Humans, PNAS, December 18, 2018, 115(51), 1303913044; published ahead of print November 26, 2018. DOI: 10.1073/pnas.1810946115.




19


 ,     (  ), ,  ,      ,        .




20


S.Rogers, Reflections on Issues Posed by Recombinant DNA Molecule Technology. II, Annals of the New York Academy of Sciences 265(1976): 6670.




21


T.Friedmann and R.Roblin, Gene Therapy for Human Genetic Disease?, Science 175(1972): 949955.




22


T.Friedmann, Stanfield Rogers: Insights into Virus Vectors and Failure of an Early Gene Therapy Model, Molecular Therapy 4(2001): 285288.




23


  2016-       ,   2018-      ,  :     15   ,    ࠖ 594 .


